Oral mucosal lipids are antimicrobial against <em>Porphyromonas gingivalis,</em> induce ultrastructural damage, and alter bacterial lipid and protein compositions
نویسنده
چکیده
Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 ORAL MUCOSAL LIPIDS ARE ANTIBACTERIAL AGAINST PORPHYROMONAS GINGIVALIS, INDUCE ULTRASTRUCTURAL DAMAGE, AND ALTER BACTERIAL LIPID AND PROTEIN COMPOSITIONS by Carol Lea Fischer A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Oral Science in the Graduate College of The University of Iowa
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The Relationship between Porphyromonas gingivalis and Rheumatoid Arthritis: a Cross-Sectional Clinical, Microbiological, and Molecular Approach
Background: The relationship between rheumatoid arthritis and poor oral hygiene has longbeen proven. Colonization of Porphyromonas gingivalis in the oral cavity can play an important role in rheumatoid arthritis. The aim of this study was to determine whether there is a relationship between rheumatoid arthritis disease and the presence of P. gingivalis. <stro...
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Induction of mucosal immune responses against Porphyromonas gingivalis within the oral cavity of dogs was studied by immunizing with pH-sensitive fusogenic polymer (MGluPG)-modified liposome-associated cell lysate. Dogs immunized with P. gingivalis cell lysate-containing MGluPG-modified liposomes by intraocular (eye drop) route displayed significant levels of P. gingivalis cell lysate-specific ...
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Porphyromonas gingivalis, a gram-negative anaerobe, is implicated in the etiology of adult periodontitis. P. gingivalis fimbriae are one of several critical surface virulence factors involved in both bacterial adherence and inflammation. P. gingivalis fimbrillin (FimA), the major subunit protein of fimbriae, is considered an important antigen for vaccine development against P. gingivalis-associ...
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OBJECTIVE Macrolide antibiotics are reported to modulate the production of cytokines in various type of cells. We examined the effect of macrolide antibiotics on inflammatory cytokines (IL-6 and IL-8) and chemical mediator (PGE(2)) and also matrix metalloproteinases (MMPs) productions by human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS). METHODS The effect of macrolide a...
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